Innate lymphoid cells in inflammatory bowel diseases

C P Peters; J M Mjösberg; J H Bernink; H Spits

doi:10.1016/j.imlet.2015.10.004

Innate lymphoid cells in inflammatory bowel diseases

Immunol Lett. 2016 Apr:172:124-31. doi: 10.1016/j.imlet.2015.10.004. Epub 2015 Oct 22.

Authors

C P Peters¹, J M Mjösberg², J H Bernink³, H Spits⁴

Affiliations

¹ Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address: c.p.peters@amc.uva.nl.
² Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge Karolinska Institutet, CIM, F59, S-14186 Stockholm, Sweden. Electronic address: jenny.mjosberg@ki.se.
³ Department of Celbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address: j.h.bernink@amc.uva.nl.
⁴ Department of Celbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address: hergen.spits@amc.uva.nl.

PMID: 26470815
DOI: 10.1016/j.imlet.2015.10.004

Abstract

It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD.

Keywords: Anti-TNF; Crohn’s disease; IBD; IFN-γ; ILC; Innate lymphoid cells; Ulcerative colitis.

Publication types

Review

MeSH terms

Animals
Antibodies, Blocking / therapeutic use
Disease Susceptibility
Humans
Immunity, Innate
Immunotherapy / methods*
Inflammatory Bowel Diseases / immunology*
Inflammatory Bowel Diseases / therapy
Interferon-gamma / metabolism
Lymphocytes / immunology*
Tumor Necrosis Factor-alpha / immunology

Substances

Antibodies, Blocking
Tumor Necrosis Factor-alpha
Interferon-gamma