The use of systems biology and immunological big data to guide vaccine development

Christoph J Blohmke; Daniel O'Connor; Andrew J Pollard

doi:10.1186/s13073-015-0236-1

The use of systems biology and immunological big data to guide vaccine development

Genome Med. 2015 Nov 10:7:114. doi: 10.1186/s13073-015-0236-1.

Authors

Christoph J Blohmke^{1

2}, Daniel O'Connor^{3

4}, Andrew J Pollard^{1

2}

Affiliations

¹ Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Pediatrics, University of Oxford, The Churchill Hospital, Old Road, Oxford, OX3 7LE, UK.
² NIHR Oxford Biomedical Research Center, The Churchill Hospital, Old Road, Oxford, OX3 7LE, UK.
³ Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Pediatrics, University of Oxford, The Churchill Hospital, Old Road, Oxford, OX3 7LE, UK. daniel.oconnor@paediatrics.ox.ac.uk.
⁴ NIHR Oxford Biomedical Research Center, The Churchill Hospital, Old Road, Oxford, OX3 7LE, UK. daniel.oconnor@paediatrics.ox.ac.uk.

Abstract

High-throughput technologies applied to the analysis of vaccine responses are likely to reveal the mechanisms responsible for vaccine-induced protection, aid understanding of vaccine safety and help accelerate vaccine development and clinical trials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomedical Research
Humans
Systems Biology*
Vaccines*

Substances

Vaccines