Neuropsychological profile in adult schizophrenia measured with the CMINDS

Theo G M van Erp; Adrian Preda; Jessica A Turner; Shawn Callahan; Vince D Calhoun; Juan R Bustillo; Kelvin O Lim; Bryon Mueller; Gregory G Brown; Jatin G Vaidya; Sarah McEwen; Aysenil Belger; James Voyvodic; Daniel H Mathalon; Dana Nguyen; Judith M Ford; Steven G Potkin; FBIRN

doi:10.1016/j.psychres.2015.10.028

Neuropsychological profile in adult schizophrenia measured with the CMINDS

Psychiatry Res. 2015 Dec 30;230(3):826-34. doi: 10.1016/j.psychres.2015.10.028. Epub 2015 Oct 26.

Authors

Theo G M van Erp¹, Adrian Preda², Jessica A Turner³, Shawn Callahan², Vince D Calhoun⁴, Juan R Bustillo⁵, Kelvin O Lim⁶, Bryon Mueller⁶, Gregory G Brown⁷, Jatin G Vaidya⁸, Sarah McEwen⁹, Aysenil Belger¹⁰, James Voyvodic¹¹, Daniel H Mathalon¹², Dana Nguyen², Judith M Ford¹², Steven G Potkin²; FBIRN

Affiliations

¹ Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA. Electronic address: tvanerp@uci.edu.
² Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
³ Departments of Psychology and Neuroscience, Georgia State University, Atlanta, GA 30303, USA; Mind Research Network, Albuquerque, NM 87106, USA.
⁴ Mind Research Network, Albuquerque, NM 87106, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 97106, USA; Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA.
⁵ Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA.
⁶ Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA.
⁷ VA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, CA 92161, USA.
⁸ Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
⁹ Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
¹⁰ Departments of Psychiatry and Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
¹¹ Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA.
¹² Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS(®)). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=-1.14), Attention/Vigilance (d=-1.04), Working Memory (d=-1.03), Verbal Learning (d=-1.02), Visual Learning (d=-0.91), and Reasoning/Problem Solving (d=-0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.

Keywords: MATRICS; MCCB; Memory; Neuropsychology; Psychosis; Sex; Speed of processing.

MeSH terms

Adult
Attention
Cognition Disorders / diagnosis*
Cognition Disorders / psychology
Cognition*
Female
Healthy Volunteers
Humans
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests*
Problem Solving
Schizophrenia / diagnosis*
Schizophrenic Psychology*
Sex Factors
Spatial Learning
Thinking
Verbal Learning

Abstract

MeSH terms

Grants and funding