Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells

Haematologica. 2016 Feb;101(2):e59-62. doi: 10.3324/haematol.2015.135590. Epub 2015 Nov 20.
No abstract available

Keywords: CD40L (CD154); cancer microenvironment; chronic lymphocytic leukemia; small molecular pathway inhibitors.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD19 / genetics
  • Antigens, CD19 / immunology
  • Antineoplastic Agents / pharmacology*
  • B-Lymphocytes / drug effects*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology
  • CD40 Ligand / antagonists & inhibitors*
  • CD40 Ligand / genetics
  • CD40 Ligand / immunology
  • CD40 Ligand / pharmacology
  • Cell Proliferation / drug effects
  • Clinical Trials as Topic
  • Cyclohexylamines / pharmacology
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Lymphocyte Activation
  • Organ Specificity
  • Oxazines / pharmacology
  • Primary Cell Culture
  • Protein Kinase Inhibitors / pharmacology*
  • Pyridines / pharmacology
  • Pyrimidines / pharmacology
  • Signal Transduction
  • Spleen / drug effects
  • Spleen / immunology
  • Spleen / pathology
  • Syk Kinase / antagonists & inhibitors*
  • Syk Kinase / genetics
  • Syk Kinase / immunology
  • Transcription Factor RelA / genetics
  • Transcription Factor RelA / immunology
  • p38 Mitogen-Activated Protein Kinases / genetics
  • p38 Mitogen-Activated Protein Kinases / immunology

Substances

  • 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(2-aminocyclohexylamino)pyrimidine-5-carboxamide
  • Antigens, CD19
  • Antineoplastic Agents
  • CD19 molecule, human
  • Cyclohexylamines
  • N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine
  • Oxazines
  • Protein Kinase Inhibitors
  • Pyridines
  • Pyrimidines
  • Transcription Factor RelA
  • CD40 Ligand
  • SYK protein, human
  • Syk Kinase
  • p38 Mitogen-Activated Protein Kinases