Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation

J Alzheimers Dis. 2016;50(1):1-7. doi: 10.3233/JAD-150614.

Abstract

We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreased Aβ40 and Aβ42. After treatment, focal symptomatology disappeared, and WML and anti-Aβ autoantibodies decreased. The APOEɛ4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.

Keywords: Biomarkers; Florbetapir-PET; cerebral amyloid angiopathy; cerebrospinal fluid; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amyloid beta-Peptides / cerebrospinal fluid
  • Amyloid beta-Peptides / immunology*
  • Aniline Compounds / pharmacokinetics
  • Apolipoproteins E / genetics
  • Autoantibodies / cerebrospinal fluid*
  • Cerebral Amyloid Angiopathy / cerebrospinal fluid*
  • Cerebral Amyloid Angiopathy / complications
  • Cerebral Amyloid Angiopathy / diagnostic imaging*
  • Cerebral Amyloid Angiopathy / genetics
  • Ethylene Glycols / pharmacokinetics
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Meningoencephalitis / complications
  • Peptide Fragments / cerebrospinal fluid
  • Positron-Emission Tomography
  • Statistics, Nonparametric
  • tau Proteins / cerebrospinal fluid

Substances

  • Amyloid beta-Peptides
  • Aniline Compounds
  • Apolipoproteins E
  • Autoantibodies
  • Ethylene Glycols
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • amyloid beta-protein (1-42)
  • tau Proteins
  • florbetapir