Rapid Emergence and Clonal Dissemination of CTX-M-15-Producing Salmonella enterica Serotype Virchow, South Korea

Emerg Infect Dis. 2016 Jan;22(1):68-70. doi: 10.3201/eid2201.151220.

Abstract

The prevalence of cefotaxime-resistant Salmonella enterica serotype Virchow has dramatically increased in South Korea since the first isolation in 2011. Of 68 isolates collected over 10 years, 28 cefotaxime-resistant isolates harbored the bla(CTX-M-15) extended-spectrum β-lactamase gene and were closely related genetically, demonstrating the clonal dissemination of CTX-M-15-producing Salmonella Virchow in South Korea.

Keywords: CTX-M-15; ESBL; IncHI2; S. enterica; Salmonella enterica; Salmonella enterica serotype Virchow; South Korea; antimicrobial resistance; bacteria; clonal dissemination; emergence; extended-spectrum β-lactamases; nontyphoidal salmonella; prevalence; salmonella; surveillance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Cefotaxime / therapeutic use
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Resistance, Multiple, Bacterial / genetics
  • Humans
  • Microbial Sensitivity Tests / methods
  • Republic of Korea / epidemiology
  • Salmonella Infections / drug therapy
  • Salmonella Infections / epidemiology*
  • Salmonella enterica / drug effects
  • Salmonella enterica / genetics*
  • Serogroup
  • Serotyping / methods
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • beta-lactamase CTX-M-15
  • beta-Lactamases
  • Cefotaxime