Abstract
Carbapenemase-producing Enterobacteriaceae may exhibit in vitro susceptibility to carbapenems, especially those producing weak carbapenemases. Routine clinical laboratories have employed phenotypic tests for screening such isolates. BKC-1 is a recently reported carbapenemase that shows weak carbapenemase activity. In this study, we aimed to evaluate the behavior of distinct phenotypic methods against BKC-1-producing Enterobacteriaceae.
Keywords:
Antimicrobial resistance; BKC-1; Carbapenemase; Klebsiella pneumoniae.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / genetics
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Carbapenems / metabolism
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Carbapenems / pharmacology
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Disk Diffusion Antimicrobial Tests
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Enterobacteriaceae / classification
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / enzymology*
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Enterobacteriaceae / genetics
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Humans
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Hydrolysis
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Microbial Sensitivity Tests* / methods
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-Lactamases
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carbapenemase