Comparison of phenotypic tests for detecting BKC-1-producing Enterobacteriaceae isolates

Diagn Microbiol Infect Dis. 2016 Mar;84(3):246-8. doi: 10.1016/j.diagmicrobio.2015.11.021. Epub 2015 Nov 27.

Abstract

Carbapenemase-producing Enterobacteriaceae may exhibit in vitro susceptibility to carbapenems, especially those producing weak carbapenemases. Routine clinical laboratories have employed phenotypic tests for screening such isolates. BKC-1 is a recently reported carbapenemase that shows weak carbapenemase activity. In this study, we aimed to evaluate the behavior of distinct phenotypic methods against BKC-1-producing Enterobacteriaceae.

Keywords: Antimicrobial resistance; BKC-1; Carbapenemase; Klebsiella pneumoniae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / genetics
  • Carbapenems / metabolism
  • Carbapenems / pharmacology
  • Disk Diffusion Antimicrobial Tests
  • Enterobacteriaceae / classification
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics
  • Humans
  • Hydrolysis
  • Microbial Sensitivity Tests* / methods
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • beta-Lactamases
  • carbapenemase