Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study

Br J Nutr. 2016 Mar 28;115(6):1080-91. doi: 10.1017/S0007114515005292. Epub 2016 Feb 3.

Abstract

We studied vitamin D intake, serum 25-hydroxyvitamin D (S-25(OH)D) concentration, determinants of S-25(OH)D and risk factors for S-25(OH)D <50 nmol/l in a population sample of Finnish children. We studied 184 girls and 190 boys aged 6-8 years, analysed S-25(OH)D by chemiluminescence immunoassay and assessed diet quality using 4-d food records and other lifestyle factors by questionnaires. We analysed the determinants of S-25(OH)D using linear regression and risk factors for S-25(OH)D <50 nmol/l using logistic regression. Mean dietary intake of vitamin D was 5·9 (sd 2·1) µg/d. Altogether, 40·8 % of children used no vitamin D supplements. Of all children, 82·4 % did not meet the recommended total vitamin D intake of 10 µg/d. Milk fortified with vitamin D was the main dietary source of vitamin D, providing 48·7 % of daily intake. S-25(OH)D was <50 nmol/l in 19·5 % of children. Consumption of milk products was the main determinant of S-25(OH)D in all children (standardised regression coefficient β=0·262; P<0·001), girls (β=0·214; P=0·009) and boys (β=0·257; P=0·003) in multivariable models. Vitamin D intake from supplements (β=0·171; P=0·035) and age (β=-0·198; P=0·015) were associated with S-25(OH)D in girls. Children who drank ≥450 g/d of milk, spent ≥2·2 h/d in physical activity, had ≥13·1 h/d of daylight time or were examined in autumn had reduced risk for S-25(OH)D <50 nmol/l. Insufficient vitamin D intake was common among Finnish children, one-fifth of whom had S-25(OH)D <50 nmol/l. More attention should be paid to the sufficient intake of vitamin D from food and supplements, especially among children who do not use fortified milk products.

Keywords: 25(OH)D 25-hydroxyvitamin D; 25-Hydroxyvitamin D; Children; Determinants; Vitamin D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 25-Hydroxyvitamin D 2 / blood*
  • Animals
  • Calcifediol / blood*
  • Child
  • Child Nutritional Physiological Phenomena*
  • Dairy Products
  • Diet / adverse effects*
  • Diet Records
  • Dietary Supplements
  • Female
  • Finland / epidemiology
  • Food, Fortified
  • Humans
  • Life Style
  • Male
  • Milk
  • Motor Activity*
  • Nutrition Surveys
  • Risk Factors
  • Seasons
  • Vitamin D / administration & dosage*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / etiology*
  • Vitamin D Deficiency / prevention & control

Substances

  • Vitamin D
  • 25-Hydroxyvitamin D 2
  • Calcifediol