Recovery from delirium and psychotic manifestations following treatment of anaemia with off-label rituximab in active cold haemagglutinin disease

Michail Kaklamanos; Sadie Regmi; David Wrench; Mark Kinirons

doi:10.1136/bcr-2015-213533

Recovery from delirium and psychotic manifestations following treatment of anaemia with off-label rituximab in active cold haemagglutinin disease

BMJ Case Rep. 2016 Feb 2:2016:bcr2015213533. doi: 10.1136/bcr-2015-213533.

Authors

Michail Kaklamanos¹, Sadie Regmi¹, David Wrench², Mark Kinirons¹

Affiliations

¹ Older Person's Unit, St Thomas Hospital, Guy's and St Thomas NHS Foundation Trust, London, UK.
² Haematology Unit, St Thomas Hospital, Guy's and St Thomas NHS Foundation Trust, London, UK.

Abstract

Anaemia is an independent, commonly under-recognised risk factor for delirium. Prompt management of anaemia and its underlying aetiology could result in recovery from delirium and associated psychotic manifestations. We report this unprecedented case of complete recovery from delirium and challenging behaviour, following treatment of autoimmune haemolytic anaemia with rituximab.

2016 BMJ Publishing Group Ltd.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Anemia, Hemolytic, Autoimmune / drug therapy*
Anemia, Hemolytic, Autoimmune / psychology
Delirium / drug therapy
Delirium / etiology*
Humans
Immunologic Factors / therapeutic use*
Male
Off-Label Use*
Rituximab / therapeutic use*
Treatment Outcome

Substances

Immunologic Factors
Rituximab