Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015

J Natl Compr Canc Netw. 2016 Feb;14(2):153-62. doi: 10.6004/jnccn.2016.0018.

Abstract

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling and risk assessment and management for hereditary cancer syndromes. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights summarize major discussion points of the 2015 NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meeting. Major discussion topics this year included multigene testing, risk management recommendations for less common genetic mutations, and salpingectomy for ovarian cancer risk reduction. The panel also discussed revisions to genetic testing criteria that take into account ovarian cancer histology and personal history of pancreatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics*
  • Female
  • Genetic Counseling / methods
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing / methods
  • Humans
  • Mutation / genetics
  • Neoplastic Syndromes, Hereditary / genetics
  • Ovarian Neoplasms / genetics*
  • Pancreatic Neoplasms / genetics
  • Risk Assessment / methods
  • Risk Factors