Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

Despo Ierodiakonou; Michael A Portelli; Dirkje S Postma; Gerard H Koppelman; Jorrit Gerritsen; Nick H T Ten Hacken; Wim Timens; H Marike Boezen; Judith M Vonk; Ian Sayers

doi:10.1183/13993003.01571-2015

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

Eur Respir J. 2016 May;47(5):1568-71. doi: 10.1183/13993003.01571-2015. Epub 2016 Feb 11.

Authors

Affiliations

¹ Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Both authors contributed equally.
² Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK Both authors contributed equally.
³ Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Dept of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁴ Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Dept of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁵ Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁶ Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁷ Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK ian.sayers@nottingham.ac.uk.

Abstract

PLAUR polymorphisms and levels are associated with markers of airway remodelling in lung biopsies of asthma patients http://ow.ly/X5Srl

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Airway Remodeling / physiology*
Asthma / genetics*
Asthma / physiopathology
Bronchi
Humans
Plasminogen / metabolism
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Urokinase-Type Plasminogen Activator / genetics*

Substances

Plasminogen
Urokinase-Type Plasminogen Activator

Grants and funding

G0400283/MRC_/Medical Research Council/United Kingdom