Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus

Tove Lekva; Errol R Norwitz; Pål Aukrust; Thor Ueland

doi:10.1007/s11892-016-0715-9

Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus

Curr Diab Rep. 2016 Apr;16(4):26. doi: 10.1007/s11892-016-0715-9.

Authors

Tove Lekva^{1

2}, Errol R Norwitz^{3

4}, Pål Aukrust^{5

6

7}, Thor Ueland^{8

9}

Affiliations

¹ Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027, Oslo, Norway. tove.lekva@rr-research.no.
² Mother Infant Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA, 02116, USA. tove.lekva@rr-research.no.
³ Mother Infant Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA, 02116, USA. enorwitz@tuftsmedicalcenter.org.
⁴ Department of Obstetrics & Gynecology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA. enorwitz@tuftsmedicalcenter.org.
⁵ Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027, Oslo, Norway. pal.aukrust@ous-hf.no.
⁶ Faculty of Medicine, University of Oslo, Oslo, Norway. pal.aukrust@ous-hf.no.
⁷ Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway. pal.aukrust@ous-hf.no.
⁸ Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027, Oslo, Norway. thor.ueland@medisin.uio.no.
⁹ Faculty of Medicine, University of Oslo, Oslo, Norway. thor.ueland@medisin.uio.no.

PMID: 26879309
DOI: 10.1007/s11892-016-0715-9

Abstract

With increasing rates of obesity and new diagnostic criteria for gestational diabetes mellitus (GDM), the overall prevalence of GDM is increasing worldwide. Women with GDM have an increased risk of maternal and fetal complications during pregnancy as well as long-term risks including higher prevalence of type 2 diabetes mellitus and cardiovascular disease. In recent years, the role of immune activation and inflammation in the pathogenesis of GDM has gained increasing attention. This monograph explores the current state of the literature as regards the expression of markers of inflammation in the maternal circulation, placenta, and adipose tissue of women with GDM.

Keywords: Adipose tissue; GDM; Placenta; Systemic inflammation.

Publication types

Review

MeSH terms

Adipose Tissue / immunology
Adipose Tissue / metabolism
Animals
Diabetes, Gestational / immunology*
Diabetes, Gestational / metabolism
Disease Progression
Female
Humans
Inflammation / immunology
Inflammation / metabolism
Obesity / complications
Placenta / immunology
Placenta / metabolism
Pregnancy