Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice

O A Levander; A L Ager Jr; V C Morris; R G May

doi:10.1093/ajcn/50.6.1237

Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice

Am J Clin Nutr. 1989 Dec;50(6):1237-9. doi: 10.1093/ajcn/50.6.1237.

Authors

O A Levander¹, A L Ager Jr, V C Morris, R G May

Affiliation

¹ Beltsville Human Nutrition Research Center, US Department of Agriculture, MD 20705.

PMID: 2688393
DOI: 10.1093/ajcn/50.6.1237

Abstract

Feeding a vitamin E-deficient diet containing 5% menhaden oil to mice affords significant protection against both a chloroquine-sensitive and a chloroquine-resistant line of the malarial parasite. Nutritional manipulation may offer a new approach to the problem of drug-resistant malaria, a rapidly emerging global threat to public health.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Chloroquine / pharmacology
Diet*
Drug Resistance
Fish Oils / administration & dosage
Fish Oils / therapeutic use*
Malaria / prevention & control*
Male
Mice
Plasmodium falciparum / drug effects
Vitamin E / administration & dosage*
Vitamin E Deficiency*

Substances

Fish Oils
Vitamin E
Menhaden oil
Chloroquine