A 1-Year-Old with Mycobacterium tuberculosis Endocarditis with Mass Spectrometry Analysis of Cardiac Vegetation Composition

J Pediatric Infect Dis Soc. 2016 Mar;5(1):85-8. doi: 10.1093/jpids/piu087. Epub 2014 Aug 27.

Abstract

In this study, we report the first case of Mycobacterium tuberculosis endocarditis in an immunocompetent child born in the United States. Mass spectrometry of the vegetation identified coagulation, humoral immune proteins, neutrophil granule proteins, and histones. Few neutrophils on histopathology suggest that neutrophil extracellular traps may contribute to tuberculous endocardiac mass formation.

Keywords: endocarditis; hemophagocytic lymphohistiocytosis; mass spectrometry; neutrophil extracellular traps; tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Bone Marrow / microbiology
  • Bone Marrow / pathology
  • Chromatography, Liquid
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / diagnostic imaging*
  • Endocarditis, Bacterial / drug therapy
  • Endocarditis, Bacterial / immunology
  • Endocardium / chemistry
  • Female
  • Humans
  • Immunocompetence*
  • Infant
  • Lymphohistiocytosis, Hemophagocytic / microbiology
  • Lymphohistiocytosis, Hemophagocytic / pathology
  • Mass Spectrometry
  • Mycobacterium tuberculosis / isolation & purification*
  • Neutrophils / immunology
  • Protein S / analysis
  • Tuberculosis, Cardiovascular / complications
  • Tuberculosis, Cardiovascular / diagnostic imaging*
  • Tuberculosis, Cardiovascular / drug therapy
  • Tuberculosis, Cardiovascular / immunology
  • United States

Substances

  • Antitubercular Agents
  • Protein S