Subjective quality of life in first-episode psychosis. A ten year follow-up study

Erlend Strand Gardsjord; Kristin Lie Romm; Svein Friis; Helene Eidsmo Barder; Julie Evensen; Ulrik Haahr; Wenche ten Velden Hegelstad; Inge Joa; Jan Olav Johannessen; Johannes Langeveld; Tor Ketil Larsen; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Per Vaglum; Thomas McGlashan; Ingrid Melle; Jan Ivar Røssberg

doi:10.1016/j.schres.2016.02.034

Subjective quality of life in first-episode psychosis. A ten year follow-up study

Schizophr Res. 2016 Apr;172(1-3):23-8. doi: 10.1016/j.schres.2016.02.034. Epub 2016 Mar 2.

Authors

Erlend Strand Gardsjord¹, Kristin Lie Romm², Svein Friis³, Helene Eidsmo Barder⁴, Julie Evensen⁵, Ulrik Haahr⁶, Wenche ten Velden Hegelstad⁷, Inge Joa⁸, Jan Olav Johannessen⁸, Johannes Langeveld⁷, Tor Ketil Larsen⁹, Stein Opjordsmoen¹⁰, Bjørn Rishovd Rund¹¹, Erik Simonsen¹², Per Vaglum¹³, Thomas McGlashan¹⁴, Ingrid Melle³, Jan Ivar Røssberg³

Affiliations

¹ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway. Electronic address: e.s.gardsjord@medisin.uio.no.
² Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway.
³ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway.
⁴ Women and Children's Division, Oslo University Hospital, 0407 Oslo, Norway.
⁵ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway; Adult Psychiatric Department Vinderen, Diakonhjemmet Hospital, 0319 Oslo, Norway.
⁶ Early Psychosis Intervention Center, Psychiatry East-Region Zealand, 4000 Roskilde, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
⁷ Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway.
⁸ Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway; Faculty of Social Sciences, University of Stavanger, 4036 Stavanger, Norway.
⁹ Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway; Department of Clinical Medicine, Section Psychiatry, University of Bergen, 5021 Bergen, Norway.
¹⁰ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.
¹¹ Department of Psychology, University of Oslo, P.O. 1094, Blindern, 0317 Oslo, Norway; Vestre Viken Hospital Trust, 3004 Drammen, Norway.
¹² Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Psychiatric Research Unit, Region Zealand, 4000 Roskilde, Denmark.
¹³ Department of Behavioural Sciences in Medicine, University of Oslo, 0318 Oslo, Norway.
¹⁴ Department of Social and Behavioural Health, Yale School of Medicine, Yale University, New Haven, CT, USA.

PMID: 26947210
DOI: 10.1016/j.schres.2016.02.034

Abstract

Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development.

Methods: A representative sample of 272 patients with a first episode psychotic disorder was included from 1997 through 2000. At 10 year follow-up 186 patients participated. QoL was measured by the Lehman's Quality of Life Interview. Linear mixed model analyses were performed to investigate longitudinal effects of baseline psychiatric symptoms and socio-economic variables and the effects of changes in the same variables on S-QoL-development.

Results: S-QoL improved significantly over the follow-up period. More contact with family and a better financial situation at baseline had a positive and longstanding effect on S-QoL-development, but changes in these variables were not associated with S-QoL-development. Higher depressive symptoms and less daily activities at baseline both had a negative independent effect, but a positive interaction effect with time on S-QoL-development indicating that the independent negative effect diminished over time. In the change analysis, increased daily activities and a decrease in depressive symptoms were associated with a positive S-QoL-development.

Conclusions: Treatment of depressive symptoms and measures aimed at increasing daily activities seem important to improve S-QoL in patients with psychosis. More contact with family and a better financial situation at baseline have a long-standing effect on S-QoL-development in FEP patients.

Keywords: Affective psychosis; First-episode psychosis; Follow-up; Quality of life; Schizophrenia.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adult
Depression / epidemiology
Female
Follow-Up Studies
Humans
Linear Models
Longitudinal Studies
Male
Prospective Studies
Psychiatric Status Rating Scales
Psychotic Disorders / epidemiology
Psychotic Disorders / psychology*
Quality of Life / psychology*
Schizophrenia* / epidemiology
Schizophrenic Psychology*

Grants and funding

MH-01654/MH/NIMH NIH HHS/United States