Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis

Jose D Vargas; Ani Manichaikul; Xin-Qun Wang; Stephen S Rich; Jerome I Rotter; Wendy S Post; Joseph F Polak; Matthew J Budoff; David A Bluemke

doi:10.1016/j.dib.2016.01.048

Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis

Data Brief. 2016 Feb 15:7:229-42. doi: 10.1016/j.dib.2016.01.048. eCollection 2016 Jun.

Authors

Jose D Vargas¹, Ani Manichaikul², Xin-Qun Wang³, Stephen S Rich⁴, Jerome I Rotter⁵, Wendy S Post⁶, Joseph F Polak⁷, Matthew J Budoff⁸, David A Bluemke⁹

Affiliations

¹ MedStar Health Research Institute, Georgetown University Hospital, Washington, District of Columbia, USA; National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.
² Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA; Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
³ Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
⁴ Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
⁵ Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, USA.
⁶ Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
⁷ Department of Radiology, Tufts University School of Medicine, Boston, MA, USA.
⁸ Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
⁹ National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.

Abstract

Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.

Keywords: Carotid intima-media thickness (CIMT); Common genetic variant; Coronary artery calcium (CAC); Single nucleotide polymorphism (SNP); Subclincal atherosclerosis.