The aim of this study was to predict response to induction chemotherapy in patients with locally advanced hypopharyngeal carcinoma by IVIM values.Twenty-eight patients with locally advanced hypopharyngeal carcinoma underwent IVIM studies using 12 different b values (b = 0, 10, 20, 30, 50, 70 100, 150, 200, 400, 800, and 1000 s/ mm). All patients underwent 2 MRI studies: a baseline exam before any treatment and a mid-treatment exam 3 weeks after induction chemotherapy. In the IVIM approach, D, f, and D were extracted from a bi-exponential fit. For comparison, the ADC map were extracted from a mono-exponential fit. At the end of induction chemotherapy, patients were classified as responders or nonresponders group according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST), based on their MRI measurement. The patients were classified into high grade group (G1), moderate grade group (G2), and low grade group (G3) according to the tumor pathological grading. The predictive value of IVIM parameters were examined with Student's t test, analysis of variance (ANOVA), and receiver operating characteristic (ROC) curves.After 2 cycles of induction chemotherapy, 18 patients were categorized into the responder group whereas the other 10 patients were considered nonresponders. Compared with the pretreatment value, the post-treatment ADC value and D value was significantly higher and the posttreatment D value was significantly lower (all P < 0.05). In contrast, post-treatment f parameter only changed slightly (P > 0.05). Compared with nonresponders, a notably lower pretreatment ADC value, D value, posttreatment D value, and higher posttreatment ADC value, D value, ΔADC, ΔD, and ΔD were observed in responders (all P < 0.05), but no significant change in Δ f among the 2 group (P > 0.05). The ROC curve analysis indicated that the cutoff of pretreatment D value in best predicting tumor's chemotherapeutic response was 0.847 × 10 mm/s, and the corresponding AUC, sensitivity, and specificity were 0.806, 75.0%, and 88.9%, respectively. Although pretreatment IVIM-derived parameters had no significant differences between high grade, moderate grade, and low grade group, a trend towards lower D was observed with increasing tumor grading from G3 to G1.IVIM-DWI can potentially predict the treatment response to induction chemotherapy for hypopharyngeal carcinoma.