Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative

Kimberly Page; Ali Mirzazadeh; Thomas M Rice; Jason Grebely; Arthur Y Kim; Andrea L Cox; Meghan D Morris; Margaret Hellard; Julie Bruneau; Naglaa H Shoukry; Gregory J Dore; Lisa Maher; Andrew R Lloyd; Georg Lauer; Maria Prins; Barbara H McGovern

doi:10.1093/ofid/ofw024

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative

Open Forum Infect Dis. 2016 Feb 8;3(1):ofw024. doi: 10.1093/ofid/ofw024. eCollection 2016 Jan.

Authors

Affiliations

¹ Division of Epidemiology, Biostatistics and Preventive Medicine , University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
² Department of Epidemiology and Biostatistics , University of California San Francisco.
³ The Kirby Institute for Infection and Immunity in Society.
⁴ Harvard Medical School , Boston, Massachusetts.
⁵ Department of Medicine , Johns Hopkins Medical Institutions , Baltimore, Maryland.
⁶ Burnet Institute , Melbourne, Victoria , Australia.
⁷ Centre Hospitalier de l'Université de Montréal , Quebec , Canada.
⁸ School of Medical Sciences , University of New South Wales , Sydney , Australia.
⁹ GGD Public Health Service of Amsterdam , The Netherlands.
¹⁰ Seres Therapeutics , Cambridge, Massachusetts.

Abstract

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.

Keywords: IFNL4; acute infection; alanine aminotransferase; hepatitis C virus; jaundice.

Abstract

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