Morphometrical analysis of placental functional efficiency in normotensive versus preeclamptic South African black women

Hypertens Pregnancy. 2016 Aug;35(3):361-70. doi: 10.3109/10641955.2016.1150488. Epub 2016 Mar 22.

Abstract

Objective: To assess the umbilical cord centrality, placental morphometrics, and functional efficiency in preeclampsia.

Methods: Placental morphometry of normotensive (n = 69) and preeclamptic (n = 69) patients was evaluated.

Results: There was a significant reduction in mean placental surface area (p = 0.0001), length (p = 0.0001), thickness (p = 0.016), and volume (p = 0.0001) in the preeclamptic than in the normotensive groups. Umbilical cord insertion was predominantly eccentric with marginal in early (29%) and late-onset preeclampsia (16%). Placental and birth weight was lower (p = 0.0001) in preeclampsia than in the normotensive group. Placental efficiency was reduced in early-onset preeclampsia.

Conclusion: This study demonstrates reduced placental morphometrics with impaired placental efficiency in preeclampsia.

Keywords: Cord insertion; morphometrics; placenta; preeclampsia; pregnancy.

MeSH terms

  • Adult
  • Black People
  • Blood Pressure / physiology
  • Female
  • Humans
  • Organ Size / physiology
  • Placenta / pathology
  • Placenta / physiopathology*
  • Pre-Eclampsia / pathology
  • Pre-Eclampsia / physiopathology*
  • Pregnancy
  • South Africa
  • Young Adult