The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells

Leukemia. 2016 Aug;30(8):1784-1788. doi: 10.1038/leu.2016.56. Epub 2016 Mar 8.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Dioxygenases
  • Hematologic Neoplasms / enzymology*
  • Hematologic Neoplasms / genetics
  • Hematopoietic Stem Cells / enzymology*
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Mutation
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Dioxygenases
  • TET2 protein, human
  • Tet2 protein, mouse