4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?

Genome Biol. 2016 Apr 7:17:54. doi: 10.1186/s13059-016-0923-2.

Abstract

Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Computational Biology / methods*
  • Models, Molecular
  • Nucleic Acid Conformation
  • Nucleosomes / chemistry*
  • Nucleosomes / genetics
  • Single-Cell Analysis / methods*
  • Spatial Analysis

Substances

  • Nucleosomes