The Impact of Variable Degrees of Freedom and Scale Parameters in Bayesian Methods for Genomic Prediction in Chinese Simmental Beef Cattle

PLoS One. 2016 May 3;11(5):e0154118. doi: 10.1371/journal.pone.0154118. eCollection 2016.

Abstract

Three conventional Bayesian approaches (BayesA, BayesB and BayesCπ) have been demonstrated to be powerful in predicting genomic merit for complex traits in livestock. A priori, these Bayesian models assume that the non-zero SNP effects (marginally) follow a t-distribution depending on two fixed hyperparameters, degrees of freedom and scale parameters. In this study, we performed genomic prediction in Chinese Simmental beef cattle and treated degrees of freedom and scale parameters as unknown with inappropriate priors. Furthermore, we compared the modified methods (BayesFA, BayesFB and BayesFCπ) with their corresponding counterparts using simulation datasets. We found that the modified methods with distribution assumed to the two hyperparameters were beneficial for improving the predictive accuracy. Our results showed that the predictive accuracies of the modified methods were slightly higher than those of their counterparts especially for traits with low heritability and a small number of QTLs. Moreover, cross-validation analysis for three traits, namely carcass weight, live weight and tenderloin weight, in 1136 Simmental beef cattle suggested that predictive accuracy of BayesFCπ noticeably outperformed BayesCπ with the highest increase (3.8%) for live weight using the cohort masking cross-validation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bayes Theorem
  • Cattle / genetics*
  • Female
  • Genomics / methods*
  • Male
  • Models, Statistical
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci / genetics

Associated data

  • Dryad/10.5061/dryad.4qc06

Grants and funding

This study was supported by Cattle Breeding Innovative Research Team (cxgc-ias-03), the 12th "Five-Year" National Science and Technology Support Project (2011BAD28B04) Basic Research Fund Program, the National High Technology Research and Development Program of China (863 Program 2013AA102505-4), Chinese Academy of Agricultural Sciences Fundamental Research Budget Increment Projects (2013ZL031 and 2014ZL006), Chinese Academy of Agricultural Sciences Foundation (2014ywf-yb-4), Beijing Natural Science Foundation (6154032), and the National Natural Science Foundations of China (31472079, 31372294, and 31402039).