Pharmacokinetic properties of sustained-release theophylline (Theolair-SR) in relation to timing of doses after low-fat meals

P W Welsh; E J O'Connell; M I Sachs; T P Moyer; K A Wick; L I Harrison; S E McCarville; D C Kvam

Pharmacokinetic properties of sustained-release theophylline (Theolair-SR) in relation to timing of doses after low-fat meals

Ann Allergy. 1989 May;62(5):396-400.

Authors

P W Welsh¹, E J O'Connell, M I Sachs, T P Moyer, K A Wick, L I Harrison, S E McCarville, D C Kvam

Affiliation

¹ Division of Allergic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.

PMID: 2719348

Abstract

Pharmacodynamic and pharmacokinetic properties of sustained-release anyhdrous theophylline (Theolair-SR) were similar when doses were given either immediately after or two hours after low-fat meals in children with moderate asthma requiring daily theophylline maintenance. Asthma and pulmonary function values were maintained and approached values for healthy subjects during both treatment regimens.

MeSH terms

Adolescent
Asthma / drug therapy
Child
Delayed-Action Preparations
Dietary Fats / administration & dosage*
Drug Administration Schedule
Female
Forced Expiratory Flow Rates
Forced Expiratory Volume
Functional Residual Capacity
Humans
Lung Volume Measurements
Male
Theophylline / blood
Theophylline / pharmacokinetics*

Substances

Delayed-Action Preparations
Dietary Fats
Theophylline