Plasma membrane repairs by small GTPase Rab3a

Camilla Raiborg; Harald Stenmark

doi:10.1083/jcb.201606006

Plasma membrane repairs by small GTPase Rab3a

J Cell Biol. 2016 Jun 20;213(6):613-5. doi: 10.1083/jcb.201606006.

Authors

Camilla Raiborg¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
² Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway stenmark@ulrik.uio.no.

Abstract

Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane repair.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcium / metabolism
Cell Membrane / metabolism*
Cell Membrane / physiology*
Eukaryotic Cells / metabolism
Eukaryotic Cells / physiology
Humans
Lysosomes / metabolism
Lysosomes / physiology
rab3A GTP-Binding Protein / metabolism*

Substances

rab3A GTP-Binding Protein
Calcium