MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

J Neuroinflammation. 2016 Jun 28;13(1):167. doi: 10.1186/s12974-016-0633-4.

Abstract

We have recently identified in a transgenic mouse model of Alzheimer's disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer's pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking.

Keywords: Amyloid precursor protein; Amyloidogenesis; IL-1β; Matrix metalloproteinases; Neurodegenerative disease; Neuroinflammation; Trafficking.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / chemically induced*
  • Alzheimer Disease / genetics*
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Cytokines / metabolism
  • Disease Models, Animal
  • Humans
  • Matrix Metalloproteinases, Membrane-Associated / metabolism*
  • Matrix Metalloproteinases, Membrane-Associated / toxicity*
  • Mice
  • Mice, Transgenic

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Cytokines
  • Matrix Metalloproteinases, Membrane-Associated
  • Mmp24 protein, mouse