Probable Griseofulvin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms in a Child

Pediatr Dermatol. 2016 Sep;33(5):e290-1. doi: 10.1111/pde.12935. Epub 2016 Jul 11.

Abstract

A 9-year-old boy presented with fever, rash, anterior cervical lymphadenopathy, high liver enzymes, atypical lymphocytosis, and eosinophilia (drug reaction with eosinophilia and systemic symptoms [DRESS]). His history was notable for having taken griseofulvin for 3 weeks prior to onset of these findings. He improved after treatment with oral prednisone. We present a rare case of probable DRESS secondary to griseofulvin.

MeSH terms

  • Antifungal Agents / adverse effects*
  • Child
  • Drug Hypersensitivity Syndrome / diagnosis*
  • Drug Hypersensitivity Syndrome / etiology*
  • Eosinophilia / chemically induced*
  • Eosinophilia / diagnosis*
  • Griseofulvin / adverse effects*
  • Humans
  • Male

Substances

  • Antifungal Agents
  • Griseofulvin