In this paper we present a relatively narrow view of a wide body of literature, the elements of which share two featuresin common: an effect on food intake, and a relationship to an ATP-sensitive K(+) channel. With only sparse direct evidence available, we propose and provide circumstantial evidence supporting the hypothesis that ATP-sensitive potassium channels are ubiquitously relevant molecular integrators of energy balance, playing a role in numerous neuronal and hormonal systems involved in the maintenance of both energy intake and energy expenditure. Further, we focus on a few of the latest findings in this area which suggest that out hypothesis, while seemingly tenable, may involve process with unexpected levels of complexity.
Keywords: CNS; Feeding behavior; Glucostatic; Kir6.x; Metabolism; Potassium channel; SUR; Sulfonylurea.