The [lactate]/[pyruvate] ratio and alcohol metabolism: experiments with naloxone in fasting normal male volunteers

C J Morgan; A A Badawy; D R Thomas; T G Dando; A Kirby

The [lactate]/[pyruvate] ratio and alcohol metabolism: experiments with naloxone in fasting normal male volunteers

Alcohol Alcohol. 1989;24(3):185-8.

Authors

C J Morgan¹, A A Badawy, D R Thomas, T G Dando, A Kirby

Affiliation

¹ South Glamorgan Health Authority, Biomedical Research Laboratory, Cardiff, Wales.

PMID: 2757695

Abstract

Naloxone administration to fasting normal male volunteers reverses the acute ethanol-induced increase in the blood [lactate]/[pyruvate] ratio, but fails to lower blood-ethanol concentration. The results are discussed in relation to factors affecting ethanol elimination and the mechanism of antagonism of acute alcohol intoxication by naloxone.

Publication types

Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alcoholic Intoxication / blood
Ethanol / pharmacokinetics*
Humans
Lactates / blood*
Lactic Acid
Male
Metabolic Clearance Rate / drug effects
Naloxone / pharmacology*
Pyruvates / blood*
Pyruvic Acid

Substances

Lactates
Pyruvates
Lactic Acid
Naloxone
Ethanol
Pyruvic Acid