DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

Yang Du; Qiao Jiang; Nicolas Beziere; Linlin Song; Qian Zhang; Dong Peng; Chongwei Chi; Xin Yang; Hongbo Guo; Gaël Diot; Vasilis Ntziachristos; Baoquan Ding; Jie Tian

doi:10.1002/adma.201601710

DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

Adv Mater. 2016 Dec;28(45):10000-10007. doi: 10.1002/adma.201601710. Epub 2016 Sep 28.

Authors

Yang Du¹, Qiao Jiang^{2

3}, Nicolas Beziere⁴, Linlin Song², Qian Zhang¹, Dong Peng¹, Chongwei Chi¹, Xin Yang¹, Hongbo Guo², Gaël Diot⁴, Vasilis Ntziachristos⁴, Baoquan Ding², Jie Tian¹

Affiliations

¹ The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
² CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
³ CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
⁴ Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München and Technische Universität München, 85764, Neuherberg, Germany.

PMID: 27679425
DOI: 10.1002/adma.201601710

Abstract

A functional cancer theranostic nanoplatform is developed, specifically tailored toward the optoacoustic modality by combining gold nanorods with DNA nanostructures (D-AuNR). DNA origami is used as an efficient delivery vehicle owing to its prominent tumor-targeting property. The D-AuNR hybrids display an enhanced tumor diagnostic sensitivity by improved optoacoustic imaging and excellent photothermal therapeutic properties in vivo.

Keywords: DNA origami; cancer; gold nanorods; optoacoustic imaging; photoacoustic imaging; photothermal therapy.