Renal Denervation for Resistant Hypertension

John P Reilly; Christopher J White

doi:10.1016/j.pcad.2016.10.003

Renal Denervation for Resistant Hypertension

Prog Cardiovasc Dis. 2016 Nov-Dec;59(3):295-302. doi: 10.1016/j.pcad.2016.10.003. Epub 2016 Oct 24.

Authors

John P Reilly¹, Christopher J White²

Affiliations

¹ Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute. Electronic address: jreilly@ocshner.org.
² Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute; Ochsner Clinical School, University of Queensland School of Medicine.

PMID: 27789315
DOI: 10.1016/j.pcad.2016.10.003

Abstract

Renal denervation as a treatment for hypertension (HTN) has been shown to be effective as a surgical procedure. Over the past 10 years, an endovascular approach to replicate the results of surgical splanchnicectomy has been investigated to replace this surgical procedure with a less invasive procedure with lower morbidity. Several devices and procedures have been developed, including a non-invasive strategy. We review the improvement of HTN in clinical trials of these devices as well as the shortcomings of these studies. Thus far, these trials have been unable to prove that these renal denervation strategies are superior to medical therapy alone, but we look forward to further randomized, double blinded trials of current systems that can effectively achieve denervation to reduce the risk of HTN.

Keywords: Anti-hypertensive agents; Denervation; Hypertension; Sympathectomy.

Publication types

Review

MeSH terms

Clinical Trials as Topic
Humans
Hypertension* / physiopathology
Hypertension* / surgery
Kidney / innervation
Sympathectomy / methods*