System administration of human recombinant lactoferrin per os to rats for 2,5 months increased serum and testicular levels of total testosterone. The data correlated with the increase in free testosterone levels. These changes were accompanied by an increase of concentrations of steroidogenesis substrates (cholesterol, progesterone, and 17-OH progesterone) and a decrease of the estradiol content in blood serum. This resulted in the 3.6-3.8-fold increase of the testosterone/estradiol index. Basic parameters of lipid and protein were also studied. Results of this study suggest that lactoferrin administration causes activation of androgen synthesis and lipid metabolism.
Sistemnoe (v techenie 2,5 mesiatsev) vvedenie per os rekombinantnogo laktoferrina cheloveka per os vyzyvalo povyshenie urovnia obshchego testosterona v syvorotke krovi i gomogenatakh semennikov éksperimental'nykh zhivotnykh, kotoroe korrelirovalo s uvelicheniem svobodnogo testosterona. V syvorotke krovi imelo mesto uvelichenie kontsentratsii substratov steroidogeneza (kholesterina, progesterona i 17-ON progesterona) i snizhenie soderzhaniia éstradiola, chto privodilo k uvelicheniiu testosteron/éstradiolovogo indeksa v 3,6-3,8 raza. Izucheny osnovnye pokazateli lipidnogo i belkovogo obmena. Poluchennye rezul'taty svidetel'stvuiut ob aktivatsii laktoferrinom sinteza androgenov i lipidnogo obmena.
Keywords: lipid and protein metabolism; recombinant human lactoferrin; steroidogenesis; testosterone.