Primate Neurons Flex Their Musclin

Alex A Pollen; Arnold R Kriegstein

doi:10.1016/j.neuron.2016.11.024

Primate Neurons Flex Their Musclin

Neuron. 2016 Nov 23;92(4):681-683. doi: 10.1016/j.neuron.2016.11.024.

Authors

Alex A Pollen¹, Arnold R Kriegstein²

Affiliations

¹ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: pollena@stemcell.ucsf.edu.
² Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.

PMID: 27883900
DOI: 10.1016/j.neuron.2016.11.024

Abstract

Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of primate neural circuits.

Keywords: MEF2C; NPR3; OSTN; activity-dependent gene expression; osteocrin/musclin; primate neocortex evolution.

MeSH terms

Animals
Gene Expression
Muscle Proteins / genetics*
Neurons*
Primates / genetics

Substances

Muscle Proteins