Refractory Chronic Rhinosinusitis with Nasal Polyposis

Benjamin P Hull; Rakesh K Chandra

doi:10.1016/j.otc.2016.08.006

Refractory Chronic Rhinosinusitis with Nasal Polyposis

Otolaryngol Clin North Am. 2017 Feb;50(1):61-81. doi: 10.1016/j.otc.2016.08.006.

Authors

Benjamin P Hull¹, Rakesh K Chandra²

Affiliations

¹ Department of Otolaryngology-Head & Neck Surgery, Vanderbilt University, 1215 21st Ave S, 7209 MCE-S, Nashville, TN 37232-8605, USA.
² Department of Otolaryngology-Head & Neck Surgery, Vanderbilt University, 1215 21st Ave S, 7209 MCE-S, Nashville, TN 37232-8605, USA. Electronic address: Rakesh.chandra@vanderbilt.edu.

PMID: 27888916
DOI: 10.1016/j.otc.2016.08.006

Abstract

Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent literature is presented regarding roles of innate immunity and superantigens. Effective treatment of CRSwNP requires careful endoscopic sinus surgery followed by an individualized treatment plan that often includes oral and topical steroids. Recidivism of polyps is common, and patients require long-term follow-up.

Keywords: Allergic fungal sinusitis; Allergy; Asthma; Cystic fibrosis; Innate immunity; Polyps; Superantigen.

Publication types

Review

MeSH terms

Chronic Disease
Combined Modality Therapy / methods
Disease Management
Humans
Immunity, Innate / drug effects
Nasal Polyps* / diagnosis
Nasal Polyps* / etiology
Nasal Polyps* / therapy
Rhinitis* / diagnosis
Rhinitis* / etiology
Rhinitis* / therapy
Sinusitis* / diagnosis
Sinusitis* / etiology
Sinusitis* / therapy