IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3

Lucia E Rameh; Ashley M Mackey

doi:10.1038/ncb3440

IQGAP1 makes PI(3)K signalling as easy as PIP, PIP₂, PIP₃

Nat Cell Biol. 2016 Nov 29;18(12):1263-1265. doi: 10.1038/ncb3440.

Authors

Lucia E Rameh¹, Ashley M Mackey²

Affiliations

¹ Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, Massachusetts 02118, USA.
² Schepens Eye Research Institute/Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.

PMID: 27897158
DOI: 10.1038/ncb3440

Abstract

Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P₃ synthesis to facilitate Akt activation in response to extracellular stimuli.

MeSH terms

Animals
Humans
Models, Biological
Neoplasms / metabolism
Phosphatidylinositol 3-Kinases / metabolism*
Phosphatidylinositol Phosphates / metabolism*
Phosphorylation
Signal Transduction*
ras GTPase-Activating Proteins / metabolism*

Substances

IQ motif containing GTPase activating protein 1
Phosphatidylinositol Phosphates
ras GTPase-Activating Proteins
Phosphatidylinositol 3-Kinases