PAPP-A: a promising therapeutic target for healthy longevity

Aging Cell. 2017 Apr;16(2):205-209. doi: 10.1111/acel.12564. Epub 2016 Dec 29.

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity.

Keywords: IGF; PAPP-A; aging.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease
  • Health*
  • Humans
  • Longevity / physiology*
  • Molecular Targeted Therapy*
  • Pregnancy-Associated Plasma Protein-A / metabolism*
  • Signal Transduction

Substances

  • Pregnancy-Associated Plasma Protein-A