Impact of G protein-coupled receptor heteromers in endocrine systems

K C Jonas; A C Hanyaloglu

doi:10.1016/j.mce.2017.01.030

Impact of G protein-coupled receptor heteromers in endocrine systems

Mol Cell Endocrinol. 2017 Jul 5:449:21-27. doi: 10.1016/j.mce.2017.01.030. Epub 2017 Jan 20.

Authors

K C Jonas¹, A C Hanyaloglu²

Affiliations

¹ Cell Biology and Genetics Research Centre, Centre for Medical and Biomedical Education, St George's, University of London, UK. Electronic address: kjonas@sgul.ac.uk.
² Institute of Reproductive and Developmental Biology, Dept. Surgery and Cancer, Imperial College London, UK.

PMID: 28115188
DOI: 10.1016/j.mce.2017.01.030

Abstract

The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease.

Keywords: Dimer; GPCR; Heteromer; Oligomer; Signaling.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease
Endocrine System / metabolism*
Health
Humans
Protein Multimerization*
Receptors, G-Protein-Coupled / metabolism*

Substances

Receptors, G-Protein-Coupled

Grants and funding

BB/1008004/1/Biotechnology and Biological Sciences Research Council/United Kingdom