Diabetes and Bone Disease

G Isanne Schacter; William D Leslie

doi:10.1016/j.ecl.2016.09.010

Diabetes and Bone Disease

Endocrinol Metab Clin North Am. 2017 Mar;46(1):63-85. doi: 10.1016/j.ecl.2016.09.010. Epub 2016 Nov 25.

Authors

G Isanne Schacter¹, William D Leslie²

Affiliations

¹ Department of Medicine, University of Manitoba, GF-335, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada.
² Department of Medicine, University of Manitoba, C5121, 409 Tache Avenue, Winnipeg, Manitoba R2H 2A6, Canada. Electronic address: bleslie@sbgh.mb.ca.

PMID: 28131137
DOI: 10.1016/j.ecl.2016.09.010

Abstract

The World Health Organization estimates that diabetes mellitus occurs in more than 415 million people; this number could double by the year 2040. Epidemiologic data have shown that the skeletal system may be a target of diabetes-mediated damage, leading to the development of diabetes-induced osteoporosis. T1D and T2D have been associated with an increased risk of fracture. Bone mineral density and fracture risk prediction tools developed for the general population capture some of the risk associated with diabetes. Recent adaptations to these tools have improved their efficacy in patients with diabetes.

Keywords: Bone; Bone mineral density; Diabetes; Dual-energy x-ray absorptiometry; Fracture; Osteoporosis.

Publication types

Review

MeSH terms

Bone Density*
Diabetes Mellitus / physiopathology*
Fractures, Bone / complications*
Humans
Osteoporosis / complications*