Finding host targets for HIV therapy

Nat Genet. 2017 Jan 31;49(2):175-176. doi: 10.1038/ng.3777.

Abstract

A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular aggregation as potential targets for therapeutic intervention.

MeSH terms

  • Antigens, CD / genetics*
  • Antigens, CD / immunology
  • CD4 Antigens / genetics*
  • CD4 Antigens / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / virology
  • Cell Adhesion
  • Cell Adhesion Molecules, Neuronal / genetics*
  • Cell Adhesion Molecules, Neuronal / immunology
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Fetal Proteins / genetics*
  • Fetal Proteins / immunology
  • Gene Expression Regulation
  • HIV Infections / immunology
  • HIV Infections / pathology
  • HIV Infections / virology
  • HIV-1 / physiology*
  • High-Throughput Screening Assays
  • Host-Pathogen Interactions
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / immunology
  • Membrane Transport Proteins / genetics*
  • Membrane Transport Proteins / immunology
  • Molecular Targeted Therapy
  • Receptors, CCR5 / genetics*
  • Receptors, CCR5 / immunology
  • Sulfate Transporters
  • Sulfotransferases / genetics*
  • Sulfotransferases / immunology
  • Virus Internalization

Substances

  • ALCAM protein, human
  • Antigens, CD
  • CCR5 protein, human
  • CD4 Antigens
  • Cell Adhesion Molecules, Neuronal
  • Fetal Proteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Receptors, CCR5
  • SLC35B2 protein, human
  • Sulfate Transporters
  • Sulfotransferases
  • TPST2 protein, human