Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study

Christine Demmo; Trine Vik Lagerberg; Sofie R Aminoff; Tone Hellvin; Levi R Kvitland; Carmen Simonsen; Beathe Haatveit; Ole A Andreassen; Ingrid Melle; Torill Ueland

doi:10.1016/j.psychres.2016.12.048

Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study

Psychiatry Res. 2017 Mar:249:286-292. doi: 10.1016/j.psychres.2016.12.048. Epub 2016 Dec 31.

Affiliations

¹ NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway; Department of Psychology, University of Oslo, Norway. Electronic address: christine.demmo@medisin.uio.no.
² NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway.
³ NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway; Department of Specialized Inpatient Treatment, Division of Mental Health Services, Akershus University Hospital, Norway.
⁴ NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway; Department of Psychology, University of Oslo, Norway.

PMID: 28142102
DOI: 10.1016/j.psychres.2016.12.048

Abstract

Neurocognitive impairment has been found to be a marked feature in bipolar disorder (BD), also in the early phase of the illness. The longitudinal course of neurocognitive functioning, however, remains sparsely investigated. The aims of the study were to investigate the course of neurocognitive function in BD I, and to what degree neurocognitive change or stability is observed also on the individual level. Forty-two patients and 153 comparable healthy controls were assessed at baseline and one-year follow-up. Compared to the healthy control (HC) group BD I patients perform significantly poorer at both baseline and follow-up across all neurocognitive domains and on most neurocognitive subtests. Neurocognitive impairment remained stable for most patients from baseline to follow-up, both on a group level and when investigating individual trajectories, indicative of a relatively stable course of neurocognitive functioning in the early phase of BD I.

Keywords: BD I disorder; First treatment; Longitudinal; Manic episodes; Neurocognitive impairment; Psychosis; Reliable change.

MeSH terms

Adult
Bipolar Disorder / diagnosis
Bipolar Disorder / psychology*
Bipolar Disorder / therapy*
Cognition Disorders / diagnosis
Cognition Disorders / psychology*
Cognition Disorders / therapy*
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests*
Time Factors
Treatment Outcome