Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.
Keywords: T cells; infection; macrophage; reservoir; resting cells; simian immunodeficiency virus; simian immunodeficiency virus RNA.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.