A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS

J Med Primatol. 2017 Apr;46(2):59-62. doi: 10.1111/jmp.12252. Epub 2017 Feb 1.

Abstract

Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.

Keywords: T cells; infection; macrophage; reservoir; resting cells; simian immunodeficiency virus; simian immunodeficiency virus RNA.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Dendritic Cells / virology
  • Encephalitis / physiopathology
  • Encephalitis / veterinary
  • Encephalitis / virology
  • Macaca mulatta*
  • Macrophages / virology
  • Male
  • Simian Acquired Immunodeficiency Syndrome / physiopathology*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / physiology*
  • T-Lymphocytes / virology