Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population

Takeo Saito; Masashi Ikeda; Ryota Hashimoto; Nakao Iwata; Members of the Clozapine Pharmacogenomics Consortium of Japan are the following; Hidenaga Yamamori; Yuka Yasuda; Michiko Fujimoto; Kenji Kondo; Ayu Shimasaki; Kohei Kawase; Masami Miyata; Taisei Mushiroda; Takeshi Ozeki; Michiaki Kubo; Kiyoshi Fujita; Naoya Kida; Minori Nakai; Taku Otsuru; Yasuhide Fukuji; Masaru Murakami; Kentaro Mizuno; Toshiaki Shiratsuchi; Shusuke Numata; Tetsuro Ohmori; Shu-Ichi Ueno; Yuji Yada; Sadakazu Tanaka; Yoshiki Kishi; Manabu Takaki; Akiko Mamoto; Norio Taniguchi; Yutaka Sawa; Haruo Watanabe; Tetsuro Noda; Yuuhei Amano; Takemi Kimura; Taku Fukao; Taro Suwa; Toshiya Murai; Masaharu Kubota; Keishi Ueda; Hideaki Tabuse; Nobuhisa Kanahara; Nobutoshi Kawai; Kiyotaka Nemoto; Manabu Makinodan; Yosuke Nishihata; Naoki Hashimoto; Ichiro Kusumi; Yasuo Fujii; Ryoji Miyata; Kyuryoku Hirakawa; Norio Ozaki

doi:10.1016/j.biopsych.2016.12.009

Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population

Biol Psychiatry. 2017 Jul 1;82(1):e9-e10. doi: 10.1016/j.biopsych.2016.12.009. Epub 2016 Dec 16.

Authors

Takeo Saito¹, Masashi Ikeda¹, Ryota Hashimoto², Nakao Iwata³; Members of the Clozapine Pharmacogenomics Consortium of Japan are the following; Hidenaga Yamamori⁴, Yuka Yasuda⁴, Michiko Fujimoto⁴, Kenji Kondo⁵, Ayu Shimasaki⁵, Kohei Kawase⁵, Masami Miyata⁶, Taisei Mushiroda⁷, Takeshi Ozeki⁷, Michiaki Kubo⁸, Kiyoshi Fujita⁹, Naoya Kida¹⁰, Minori Nakai¹⁰, Taku Otsuru¹⁰, Yasuhide Fukuji¹⁰, Masaru Murakami¹¹, Kentaro Mizuno¹², Toshiaki Shiratsuchi¹², Shusuke Numata¹³, Tetsuro Ohmori¹³, Shu-Ichi Ueno¹⁴, Yuji Yada¹⁵, Sadakazu Tanaka¹⁵, Yoshiki Kishi¹⁵, Manabu Takaki¹⁶, Akiko Mamoto¹⁷, Norio Taniguchi¹⁷, Yutaka Sawa¹⁸, Haruo Watanabe¹⁸, Tetsuro Noda¹⁹, Yuuhei Amano²⁰, Takemi Kimura²¹, Taku Fukao²², Taro Suwa²³, Toshiya Murai²³, Masaharu Kubota²⁴, Keishi Ueda²⁵, Hideaki Tabuse²⁶, Nobuhisa Kanahara²⁷, Nobutoshi Kawai²⁸, Kiyotaka Nemoto²⁹, Manabu Makinodan³⁰, Yosuke Nishihata³⁰, Naoki Hashimoto³¹, Ichiro Kusumi³¹, Yasuo Fujii³², Ryoji Miyata³², Kyuryoku Hirakawa³³, Norio Ozaki³⁴

Affiliations

¹ Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi.
² Department of Psychiatry, Osaka University Graduate School of Medicine; Molecular Research Center for Children׳s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan.
³ Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi. Electronic address: nakao@fujita-hu.ac.jp.
⁴ Department of Psychiatry, Osaka University Graduate School of Medicine.
⁵ Department of Psychiatry, Fujita Health University School of Medicine.
⁶ Center for Research Promotion and Support, Fujita Health University.
⁷ Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences.
⁸ RIKEN Center for Integrative Medical Sciences.
⁹ Department of Psychiatry, Okehazama Hospital.
¹⁰ National Hospital Organization Ryukyu Hospital.
¹¹ National Hospital Organization Sakakibara Hospital.
¹² Wakakusa Hospital.
¹³ Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School.
¹⁴ Department of Neuropsychiatry, Ehime University Graduate School of Medicine.
¹⁵ Okayama Psychiatric Medical Center.
¹⁶ Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
¹⁷ Asakayama General Hospital.
¹⁸ Sawa Hospital.
¹⁹ Osaka Psychiatric Medical Center.
²⁰ Kakamigahara Hospital.
²¹ Division of Clinical Research, National Hospital Organization Kikuchi Hospital.
²² Department of Psychiatry, Gifu University Graduate School of Medicine.
²³ Department of Psychiatry, Graduate School of Medicine, Kyoto University.
²⁴ Kusakabe Memorial Hospital.
²⁵ Kumamotoseimei Hospital.
²⁶ Holy Cross Hospital.
²⁷ Chiba University Center for Forensic Mental Health.
²⁸ Department of Psychiatry, Mitsukaido Kosei Hospital.
²⁹ Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba.
³⁰ Department of Psychiatry, Faculty of Medicine, Nara Medical University.
³¹ Department of Psychiatry, Hokkaido University Graduate School of Medicine.
³² Yamanashi Prefectural Kita Hospital.
³³ Matsubara Hospital.
³⁴ Department of Psychiatry, Nagoya University Graduate School of Medicine.

PMID: 28161127
DOI: 10.1016/j.biopsych.2016.12.009

No abstract available

Publication types

Letter
Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Agranulocytosis / chemically induced*
Agranulocytosis / genetics*
Antipsychotic Agents / adverse effects
Asian People / genetics*
Case-Control Studies
Chromosomes, Human, Pair 12 / genetics*
Clozapine / adverse effects*
Genetic Predisposition to Disease / genetics*
Humans
Japan
Polymorphism, Single Nucleotide / genetics

Substances

Antipsychotic Agents
Clozapine