Abstract
Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalprenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of beta-adrenergic receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Naphthylamine / administration & dosage*
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1-Naphthylamine / analogs & derivatives
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Animals
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Autoradiography
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Dihydroalprenolol / metabolism
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Frontal Lobe / drug effects
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Frontal Lobe / metabolism*
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In Vitro Techniques
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Male
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Naphthalenes / administration & dosage*
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Parietal Lobe / drug effects
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Parietal Lobe / metabolism*
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic, beta / drug effects
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Receptors, Adrenergic, beta / metabolism*
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Serotonin / metabolism*
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Sertraline
Substances
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Naphthalenes
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Receptors, Adrenergic, beta
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Serotonin
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Dihydroalprenolol
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1-Naphthylamine
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Sertraline