Oxygenases, including lipoxygenases and cytochrome P450s, generate an array of structurally diverse oxylipins that modulate distinct biological responses in mammals. Depending on the source of tissues and enzymes, distinct oxylipins are generated with inherent cellular function. Here, we report structurally different forms of 12-HETrE, with distinct biological function in tissues as well as their derived enzymatic source.
Keywords: 12(R)-HETrE; 12(S)-HETrE; Arachidonic acid; Dihomo-gamma-linolenic acid; Platelet 12-LOX; Thrombosis.
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