Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development

Carolyn L Bayer; Bogdan J Wlodarczyk; Richard H Finnell; Stanislav Y Emelianov

doi:10.1364/BOE.8.000757

Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development

Biomed Opt Express. 2017 Jan 10;8(2):757-763. doi: 10.1364/BOE.8.000757. eCollection 2017 Feb 1.

Authors

Carolyn L Bayer¹, Bogdan J Wlodarczyk², Richard H Finnell², Stanislav Y Emelianov³

Affiliations

¹ Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX 78712, USA; Currently with the Department of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA 70118, USA.
² Dell Pediatric Research Institute, Department of Nutritional Sciences, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA.
³ Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX 78712, USA; Currently with the School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, GA 30332, USA.

Abstract

Few technologies are capable of imaging in vivo function during development. In this study, we have implemented spectral photoacoustic imaging to estimate tissue oxygenation longitudinally in pregnant mice. We used the spectral photoacoustic signal to estimate hemoglobin oxygen saturation within intact, in vivo mouse concepti from developmental day (E) 8.5 to E16.5-a first step towards functional imaging of the maternal-fetal environment. Future work will apply these methods to compare longitudinal functional changes during normal vs abnormal development of embryos, fetuses, and placentas.

Keywords: (100.1830) Deconvolution; (170.2655) Functional monitoring and imaging; (170.5120) Photoacoustic imaging; (170.7170) Ultrasound.

Grants and funding

P01 HD067244/HD/NICHD NIH HHS/United States