Malaria Parasite Invasion: Achieving Superb Resolution

Jake Baum; Dave Richard; David T Riglar

doi:10.1016/j.chom.2017.02.006

Malaria Parasite Invasion: Achieving Superb Resolution

Cell Host Microbe. 2017 Mar 8;21(3):294-296. doi: 10.1016/j.chom.2017.02.006.

Authors

Jake Baum¹, Dave Richard², David T Riglar³

Affiliations

¹ Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. Electronic address: jake.baum@imperial.ac.uk.
² Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, QC G1V 0A6, Canada.
³ Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

PMID: 28279334
DOI: 10.1016/j.chom.2017.02.006

Abstract

It is only in the last decade that sub-cellular resolution of red cell invasion by the malaria parasite Plasmodium falciparum has been possible. Here we look back on the development of methodologies that led to this possibility and the subsequent advancements made in understanding this key event in malaria disease.

Keywords: erythrocyte; invasion; malaria; merozoite; plasmodium; super resolution microscopy; tight junction.

Publication types

Review

MeSH terms

Endocytosis*
Erythrocytes / parasitology*
Erythrocytes / ultrastructure
Image Processing, Computer-Assisted / methods
Optical Imaging / methods*
Parasitology / methods
Plasmodium falciparum / physiology*
Plasmodium falciparum / ultrastructure