Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Jonathan Rabinowitz; Nina R Schooler; Ariana Anderson; Lindsay Ayearst; David Daniel; Michael Davidson; Anzalee Khan; Bruce Kinon; Francois Menard; Lewis Opler; Mark Opler; Joanne B Severe; David Williamson; Christian Yavorsky; Jun Zhao; ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

doi:10.1016/j.schres.2017.03.017

Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Schizophr Res. 2017 Dec:190:74-76. doi: 10.1016/j.schres.2017.03.017. Epub 2017 Mar 9.

Authors

Jonathan Rabinowitz¹, Nina R Schooler², Ariana Anderson³, Lindsay Ayearst⁴, David Daniel⁵, Michael Davidson⁶, Anzalee Khan⁷, Bruce Kinon⁸, Francois Menard⁹, Lewis Opler¹⁰, Mark Opler¹¹, Joanne B Severe¹², David Williamson¹³, Christian Yavorsky¹⁴, Jun Zhao¹⁵; ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

Affiliations

¹ Bar Ilan University, Ramat Gan, Israel. Electronic address: Jonathan.Rabinowitz@biu.ac.il.
² SUNY Downstate Medical Center, Brooklyn, NY, USA.
³ UCLA, Department of Psychiatry and Biobehavioral Sciences, 760 Westwood Plaza, Ste. 28-224, Los Angeles, CA 90095, USA.
⁴ Multi-Health Systems, Inc., Research & Development, Clinical/Education/Public Safety Division, 3770 Victoria Park Avenue, Toronto, ON M2H 3M6, Canada.
⁵ Bracket Global, LLC, PO Box 7137, McLean, VA 22106, USA.
⁶ Tel Aviv University, Tel Aviv, Israel.
⁷ Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
⁸ Lundbeck LLC, 6 Parkway North, Suite 400, Deerfield, IL 60015, USA.
⁹ Groupe Hospitalier COCHIN, Pavillon TARNIER, 27 rue du Faubourg Saint-Jacques, France.
¹⁰ Long Island University, 1 University Plaza, Brooklyn, NY 11201, USA.
¹¹ ProPhase LLC, 3 Park Avenue, New York, NY 10016 & NYU School of Medicine, Dept. of Psychiatry, 1 Park Avenue, New York, NY 10016, USA.
¹² 11629 Danville Drive, Rockville, MD 20852, USA.
¹³ Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Rd, Titusville, NJ 08560, USA.
¹⁴ Cronos CCS, 201 South Main Street, Lambertville, NJ 08530, USA.
¹⁵ Abbvie Pharma, R436, Bldg AP9A-2, 1 North Waukegan Road, North Chicago, IL 60064, USA.

Abstract

International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Clinical Trials as Topic
Databases as Topic
Humans
Psychiatric Status Rating Scales*
Quality Improvement*
Reproducibility of Results
Schizophrenia / diagnosis*

Abstract

Publication types

MeSH terms

Grants and funding