Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in clinical practice, and the spectrum of NAFLD includes nonalcoholic simple fatty liver, nonalcoholic steatohepatitis, and liver cirrhosis. Some patients may even progress to hepatocellular carcinoma. At present, the gold standard for the diagnosis of NAFLD is liver biopsy, but since this is an invasive examination and has high costs, its application is limited in clinical practice. More and more studies have focused on noninvasive diagnostic methods for NAFLD, including serological markers, fatty liver predictive model, and imaging examinations. Emerging diagnostic techniques, including genomics, proteomics, glycomics, and metabolomics, also play an important role in the diagnosis of NAFLD.
非酒精性脂肪性肝病是临床最常见的慢性肝病，其疾病谱包括非酒精性脂肪肝、非酒精性脂肪性肝炎、肝硬化，部分患者会进展为肝细胞性肝癌。目前，非酒精性脂肪性肝病的诊断"金标准"仍为肝活组织检查，但这为有创检查，且价格高，在临床应用中存在一定局限。更多的研究则关注非酒精性脂肪性肝病的非侵入性诊断方法，包括血清学标志物、脂肪肝预测模型和影像学检查。新兴的诊断技术，包括基因组学、蛋白质组学、糖组学和代谢组学，也在非酒精性脂肪性肝病的诊断中起到越来越大的作用。.
Keywords: Diagnosis; Fatty liver; Non-alcoholic steatohepatitis.