Ketamine reduces the need for intubation in patients with acute severe mental illness and agitation requiring transport to definitive care: An observational study

Emerg Med Australas. 2017 Jun;29(3):291-296. doi: 10.1111/1742-6723.12763. Epub 2017 Mar 20.

Abstract

Objectives: The aim of this study was to review mental health patients transported by a dedicated statewide critical care retrieval team before and after the implementation of a ketamine sedation guideline.

Methods: This is a a retrospective cohort study of mental health patients with acute behavioural disturbance, transported between January 2010 and December 2015.

Results: A total of 78 patients were transported in the study period, 50 before and 28 after implementation of the ketamine guideline in June 2013. The introduction of the ketamine guideline was associated with a significant reduction in intubation for transport (36.00 vs 7.14%) (odds ratio 0.14, 95% confidence interval 0.02-0.71, P < 0.01). The likelihood of utilising ketamine for non-intubated patients (n = 58) was higher in the period after implementation (37.50 vs 84.62%, odds ratio 9.17, 95% confidence interval 2.54-33.08, P < 0.005). The incidence of complications in our series was low.

Conclusions: The implementation of a ketamine clinical practice guideline for agitated mental health patients was associated with an increase in the number of patients receiving ketamine as part of their sedation regime and a reduction in the number of patients requiring intubation for transport. Appropriately trained critical care retrieval teams should consider ketamine as part of the sedation regime for agitated mental health patients.

Keywords: aeromedical; intubation; ketamine; mental health; psychiatric; retrieval; sedation; transport.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Cohort Studies
  • Emergency Medical Services / methods
  • Female
  • Humans
  • Hypnotics and Sedatives / pharmacology
  • Hypnotics and Sedatives / therapeutic use
  • Intubation, Intratracheal / statistics & numerical data*
  • Ketamine / pharmacology
  • Ketamine / therapeutic use*
  • Male
  • Mental Disorders / drug therapy*
  • Middle Aged
  • Patient Transfer / trends*
  • Retrospective Studies

Substances

  • Hypnotics and Sedatives
  • Ketamine