ESCRTing Necroptosis

Hongyan Guo; William J Kaiser

doi:10.1016/j.cell.2017.03.030

ESCRTing Necroptosis

Cell. 2017 Apr 6;169(2):186-187. doi: 10.1016/j.cell.2017.03.030.

Authors

Hongyan Guo¹, William J Kaiser²

Affiliations

¹ Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Heath San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
² Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Heath San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Electronic address: kaiserw@uthscsa.edu.

PMID: 28388403
DOI: 10.1016/j.cell.2017.03.030

Abstract

Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.

Publication types

Comment

MeSH terms

Apoptosis
Necrosis
Phosphorylation
Protein Kinases*
Receptor-Interacting Protein Serine-Threonine Kinases*

Substances

Protein Kinases
Receptor-Interacting Protein Serine-Threonine Kinases

Grants and funding

DP5 OD012198/OD/NIH HHS/United States