Stage IV colorectal cancer primary site and patterns of distant metastasis

Jamaica R Robinson; Polly A Newcomb; Sheetal Hardikar; Stacey A Cohen; Amanda I Phipps

doi:10.1016/j.canep.2017.04.003

Stage IV colorectal cancer primary site and patterns of distant metastasis

Cancer Epidemiol. 2017 Jun:48:92-95. doi: 10.1016/j.canep.2017.04.003. Epub 2017 Apr 21.

Authors

Jamaica R Robinson¹, Polly A Newcomb², Sheetal Hardikar³, Stacey A Cohen⁴, Amanda I Phipps⁵

Affiliations

¹ Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St., Health Sciences Building, F-262, Seattle, WA, 98195, USA. Electronic address: jrrobins@fredhutch.org.
² Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St., Health Sciences Building, F-262, Seattle, WA, 98195, USA. Electronic address: pnewcomb@fredhutch.org.
³ Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St., Health Sciences Building, F-262, Seattle, WA, 98195, USA. Electronic address: shardika@fredhutch.org.
⁴ Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA; Department of Medicine, University of Washington, 1959 NE Pacific St., Health Sciences Building, RR-512, Seattle, WA, 98195, USA. Electronic address: shiovitz@uw.edu.
⁵ Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St., Health Sciences Building, F-262, Seattle, WA, 98195, USA. Electronic address: aphipps@fredhutch.org.

Abstract

Background: Although colorectal cancer (CRC) usually metastasizes to the liver and/or lungs, factors influencing the anatomic pattern of metastases remain poorly understood.

Methods: We assessed the relationship between primary CRC site and pattern of synchronous metastasis among 1202 individuals diagnosed with incident metastatic CRC between 2010 and 2014 and identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) registry. Polytomous logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between primary tumor site and synchronous metastatic pattern.

Results: Compared to patients with proximal colon primaries, patients with rectal primaries were more likely to present with lungs-only or liver and lungs metastases versus liver-only metastases (OR_{lungs-onlyvs.liver-only}: 2.39, 95% CI: 1.35-4.24, OR_{liver+lungsvs.liver-only}: 2.20, 95% CI: 1.46-3.32).

Conclusion: These findings suggest that patients with rectal primaries are more likely than patients with colon primaries to present with synchronous lung metastases.

Keywords: Colonic neoplasms; Colorectal neoplasms; Epidemiology; Neoplasm metastasis; Population-based cancer registry; Rectal neoplasms.

MeSH terms

Aged
Colorectal Neoplasms / epidemiology*
Female
Humans
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging

Abstract

MeSH terms

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